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Dr. Sina Barghahn

"Regulated cell death (RCD) is a tightly controlled process that leads to the deconstruction and elimination of specific cells. In plants, RCD is crucial for proper development and responses to abiotic and biotic stresses. During plant-microbe interactions, the success or failure of a plant to defend itself against potential pathogens depends on RCD. Initiation and execution of RCD often involves the activity of proteases. Extensive studies revealed numerous components of a molecular network controlling RCD and caspases as main executioners of RCD in animals. In plants, however, proteases, their respective substrates and released products as well as the underlying molecular machinery involved in RCD are poorly understood. My project aims to link the activity of specific proteases in response to different RCD triggers. I want to identify substrates and products of the activated proteases and elucidate their involvement in cell to cell signaling and execution of RCD."

University of Cologne

CEPLAS / Institiute for Plant Sciences
Chair of Terrestrial Microbiology
Zülpicher Straße 47a
D-50674 Cologne

Tel:  +49 221-470-5882
Fax: +49 221-470-7406